Random-effects meta-analysis of Phase I dose-finding studies using stochastic process priors
نویسندگان
چکیده
Phase I dose-finding studies aim at identifying the maximal tolerated dose (MTD). It is not uncommon that several are conducted, although often with some variation in administration mode or panel. For instance, sorafenib (BAY 43-900) was used as monotherapy least 29 phase trials according to a recent search clinicaltrials.gov. Since toxicity may be directly related specific indication, synthesizing information from might worthwhile. However, this rarely done practice and only fixed-effect meta-analysis framework proposed date. We developed Bayesian random-effects methodology pool suggest MTD. A curve free hierarchical model on logistic scale random effects, accounting for between-trial heterogeneity, probability of across investigated doses. An Ornstein-Uhlenbeck Gaussian process adopted effects structure. Prior distributions based latent Gamma process. extensive simulation study showed good performance method also under deviations. Sharing between can improve precision MTD selection, when number reasonably large.
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ژورنال
عنوان ژورنال: The Annals of Applied Statistics
سال: 2021
ISSN: ['1941-7330', '1932-6157']
DOI: https://doi.org/10.1214/20-aoas1390